Protein Data Bank (PDB)

Monday,12th October 2009

We have learned so many thing in today's class of computer in science such as HTML,PDB and so on..i don't want to highlight about HTML because it is common nowadays..
but the thing that i would like to share is PDB because it is quite related to my studies PDB which stands for Protein data bank because it is quite new for me..

Here are some example of it

Trypsine

First of all i would like to brief about the history of PDB

The PDB originated as a grassroots effort In 1971, Walter Hamilton of the Brookhaven National Laboratory agreed to set up the data bank at Brookhaven. Upon Hamilton's death in 1973, Tom Koeztle took over direction of the PDB. In January, 1994, Joel sussman was appointed head of the PDB.

Leucine

In October, 1998the PDB was transferred to the Research Collaboratory for sturctural Bioinformatics (RCSB), the transfer was completed in June, 1999. The new director was Helen M. berman of Rutger's University (one of the member institutions of the RCSB).
In 2003, with the formation of the wwPDB, the PDB became an international organization. Each of the four members of wwPDB can act as deposition, data processing and distribution centers for PDB data. The data processing refers to the fact that wwPDB staff review and annotates each submitted entry. The data are then automatically checked for plausibility.

Next,there are few experimental method of the PDB which are xray diffraction,NMR,electron microscopy,hybrid and others..The most structures are determined by X-ray diffraction, but about 15% of structures are now determined by NMR, and a few are determined by electron microscopy.

Protein Data Bank

• A respiratory for 3 D biological macromolecular structure

• All data are available to the public
• It includes protein,nucleic acid,and viruses
• Obtained by xray crytallography (80%)or NMR spectroscopy(16%)
• Submitted by biologist & biochemist from aroud the world

Trypsine